TY - JOUR
T1 - Acute effect of infection by adipogenic human adenovirus Ad36
AU - Pasarica, Magdalena
AU - Loiler, Scott
AU - Dhurandhar, Nikhil V.
N1 - Funding Information:
This work was funded by NIH1R01DK066164 awarded to NVD.
PY - 2008/11
Y1 - 2008/11
N2 - Human adenovirus Ad36 is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. We inoculated rats with Ad36 or UV-inactivated Ad36, or mock-infected them. Four days later, Ad36-infected rats showed 23% greater epididymal fat pad weight and viral mRNA; the viral DNA could also be detected in tissues viz. the liver, brain, and adipose tissue. Intranasal or intra-peritoneal routes of viral inoculation showed similar tissue affinity. The serum cytokine response was markedly down-regulated. Ad36 acutely suppresses the systemic immune response and spreads widely. This information will help to determine Ad36 tissue tropism and its metabolic consequences.
AB - Human adenovirus Ad36 is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. We inoculated rats with Ad36 or UV-inactivated Ad36, or mock-infected them. Four days later, Ad36-infected rats showed 23% greater epididymal fat pad weight and viral mRNA; the viral DNA could also be detected in tissues viz. the liver, brain, and adipose tissue. Intranasal or intra-peritoneal routes of viral inoculation showed similar tissue affinity. The serum cytokine response was markedly down-regulated. Ad36 acutely suppresses the systemic immune response and spreads widely. This information will help to determine Ad36 tissue tropism and its metabolic consequences.
UR - http://www.scopus.com/inward/record.url?scp=55949134300&partnerID=8YFLogxK
U2 - 10.1007/s00705-008-0219-2
DO - 10.1007/s00705-008-0219-2
M3 - Article
C2 - 18830560
AN - SCOPUS:55949134300
SN - 0304-8608
VL - 153
SP - 2097
EP - 2102
JO - Archives of Virology
JF - Archives of Virology
IS - 11
ER -