Global entrepreneurship may be defined to be the creation of new, value-adding transactions or transaction streams anywhere on the globe. The objective of this chapter is to present and examine a theory of global entrepreneurship. At the World Economic Forum held in Davos, Switzerland, in January 1999, UN Secretary General Kofi Annan called for global entrepreneurship to meet the needs of the disadvantaged and the requirements of future generations. This chapter first presents a transaction cognition theory of global entrepreneurship that is intended as a path for research that responds to this call. Second, this chapter examines the theory from three critical viewpoints: (1) capability for explanation; (2) theoretical and operational utility; and (3) verifiability through the logic of scientific inference, and presents likely propositions that are surfaced by the analysis. Finally in this chapter, some of the likely implications of this theory within the context of globalization are discussed.