A simple sample preparation for enhancing the sensitivity of mass spectrometric oligosaccharide determinations through the use of an adsorptive hydrophobic resin

Y. Huang, Y. Mechref, J. Tian, H. Gong, W. J. Lennarz, M. V. Novotny

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A simple microadsorption technique is described to remove detergent additives from oligosaccharide samples before their mass spectrometric analysis. The described methodology has been validated with submicrogram quantities of contaminated glycoproteins. This procedure is applicable to investigating minute quantities of glycans in both the positive- and negative-ion mode of matrix-assisted laser desorption/ionization mass spectrometry. (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)1233-1237
Number of pages5
JournalRapid Communications in Mass Spectrometry
Volume14
Issue number14
DOIs
StatePublished - 2000

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