A simple and convenient method for the synthesis of N, N-diaryl tertiary amines

Francis Wekesa; Neha Phadke; Claire Jahier; David B. Cordes; Michael Findlater

A simple and convenient method for the synthesis of N, N-diaryl tertiary amines

Francis Wekesa, Neha Phadke, Claire Jahier, David B. Cordes, Michael Findlater

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants. © Georg Thieme Verlag Stuttgart • New York.

Original language	English
Pages (from-to)	1046-1051
Journal	Synthesis (Germany)
State	Published - Jan 1 2014

Cite this

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title = "A simple and convenient method for the synthesis of N, N-diaryl tertiary amines",

abstract = "Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants. {\textcopyright} Georg Thieme Verlag Stuttgart • New York.",

author = "Francis Wekesa and Neha Phadke and Claire Jahier and Cordes, {David B.} and Michael Findlater",

year = "2014",

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T1 - A simple and convenient method for the synthesis of N, N-diaryl tertiary amines

AU - Wekesa, Francis

AU - Phadke, Neha

AU - Jahier, Claire

AU - Cordes, David B.

AU - Findlater, Michael

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants. © Georg Thieme Verlag Stuttgart • New York.

AB - Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants. © Georg Thieme Verlag Stuttgart • New York.

M3 - Article

SP - 1046

EP - 1051

JO - Synthesis (Germany)

JF - Synthesis (Germany)

ER -

A simple and convenient method for the synthesis of N, N-diaryl tertiary amines

Abstract

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