A review of chemical gradient systems for cell analysis

Himali Somaweera; Akif Ibraguimov; Dimitri Pappas

doi:10.1016/j.aca.2015.12.008

A review of chemical gradient systems for cell analysis

Himali Somaweera, Akif Ibraguimov, Dimitri Pappas

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Microfluidic spatial and temporal gradient generators have played an important role in many biological assays such as in the analysis of wound healing, inflammation, and cancer metastasis. Chemical gradient systems can also be applied to other fields such as drug design, chemical synthesis, chemotaxis, etc. Microfluidic systems are particularly amenable to gradient formation, as the length scales used in chips enable fluid processes that cannot be conducted in bulk scale. In this review we discuss new microfluidic devices for gradient generation and applications of those systems in cell analysis.

Original language	English
Pages (from-to)	7-17
Number of pages	11
Journal	Analytica Chimica Acta
Volume	907
DOIs	https://doi.org/10.1016/j.aca.2015.12.008
State	Published - 2016

Keywords

Gradient
Lab on a chip
Microfluidics
Review

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10.1016/j.aca.2015.12.008

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abstract = "Microfluidic spatial and temporal gradient generators have played an important role in many biological assays such as in the analysis of wound healing, inflammation, and cancer metastasis. Chemical gradient systems can also be applied to other fields such as drug design, chemical synthesis, chemotaxis, etc. Microfluidic systems are particularly amenable to gradient formation, as the length scales used in chips enable fluid processes that cannot be conducted in bulk scale. In this review we discuss new microfluidic devices for gradient generation and applications of those systems in cell analysis.",

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AU - Ibraguimov, Akif

AU - Pappas, Dimitri

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AB - Microfluidic spatial and temporal gradient generators have played an important role in many biological assays such as in the analysis of wound healing, inflammation, and cancer metastasis. Chemical gradient systems can also be applied to other fields such as drug design, chemical synthesis, chemotaxis, etc. Microfluidic systems are particularly amenable to gradient formation, as the length scales used in chips enable fluid processes that cannot be conducted in bulk scale. In this review we discuss new microfluidic devices for gradient generation and applications of those systems in cell analysis.

KW - Gradient

KW - Lab on a chip

KW - Microfluidics

KW - Review

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JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

A review of chemical gradient systems for cell analysis

Abstract

Keywords

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