A pathogenic challenge model for adult Northern Bobwhite (Colinus virginianus) using a vaccine strain of Pasteurella multocida type 3

C. B. Dabbert, R. L. Lochmiller, R. J. Morton, K. C. Powell

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A pathogenic challenge model causing approximately 50% mortality was developed in adult Northern bobwhite (Colinus virginianus) using Avichol®, a live vaccine containing the Clemson University (CU) strain of Pasteurella multocida Type 3. A dose of 2300 or 3000 colony-forming units (CPU) of Avichol® injected intramuscularly resulted in 30 to 75% mortality, whereas a dose of 230 CPU or less resulted in no mortality, and 58,720 CPU or more resulted in death in all birds challenged. Primary and secondary vaccination of Northern bobwhite with a formalinized anaculture of Avichol®-derived P. multocida resulted in protection against challenge in three separate experiments. Dexamethasone treatment of birds during vaccination resulted in decreased protection against challenge exposure.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalAvian diseases
Volume40
Issue number1
DOIs
StatePublished - 1996

Keywords

  • Colinus virginianus
  • Dexamethasone
  • Northern bobwhite
  • Pasteurella multocida
  • Vaccination

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