A Novel Coaptation Plate Device for Functional Mitral Regurgitation: An In Vitro Study

Zhaoming He, Kailiang Zhang, Bo Gao

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A novel mitral valve repair device, coaptation plate (CP), was proposed to treat functional mitral regurgitation. The objective of this study was to test efficacy of the CP in an in vitro model of functional mitral regurgitation. Ten fresh porcine mitral valves were mounted in a left heart simulator, Mitral regurgitation was emulated by means of annular dilatation, and the asymmetrical or symmetrical papillary muscles (PM) displacement. A rigid and an elastic CPs were fabricated and mounted in the orifice of regurgitant mitral valves. Steady flow leakage in a hydrostatic condition and regurgitant volume in a pulsatile flow were measured before and after implantation of the CPs. The rigid and elastic CPs reduced mitral valve regurgitant volume fraction from 60.5 ± 11.4 to 35 ± 11.6 and 36.5 ± 9.9%, respectively, in the asymmetric PM displacement. Mitral regurgitation was much lower in the symmetric PM displacement than in the asymmetric PM displacement, and was not significantly reduced after implantation of either CP. In conclusion, both the rigid and elastic CPs are effective and have no difference in reduction of functional mitral regurgitation. The CP does not aggravate mitral valve coaptation and may be used as a preventive way.

Original languageEnglish
Pages (from-to)2039-2047
Number of pages9
JournalAnnals of Biomedical Engineering
Issue number10
StatePublished - Oct 2014


  • Coaptation mechanism
  • Ischemic mitral regurgitation
  • Mitral valve plug
  • Tissue mechanics


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