A novel approach to Morita-Baylis-Hillman (MBH) lactones via the Lewis acid-promoted couplings of α,β-unsaturated lactone with aldehydes

Subramanian Karur, Justin Hardin, Allan Headley, Guigen Li

Research output: Contribution to journalArticle

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Abstract

The Morita-Baylis-Hillman (MBH)-type reaction of α,β unsaturated δ-lactone with various aldehydes has been achieved without the direct use of a Lewis base. The new MBH process can be conveniently carried out by the slow addition of the diethylaluminum iodide into the solution of lactone and aldehyde in dichloromethane at 0°C. Modest to good yields were obtained (50-65%) for eight examples.

Original languageEnglish
Pages (from-to)2991-2994
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number14
DOIs
StatePublished - Mar 31 2003

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