A non-LTR retroelement extinction in Spermophilus tridecemlineatus

Roy N. Platt, David A. Ray

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The typical mammalian genome is dominated by two types of transposable elements (TEs), the autonomous and non-autonomous non-LTR retrotransposons, i.e. LINEs and SINEs, and with few exceptions there is a sole active LINE family (L1). During an ongoing investigation of TEs in rodents we determined that overall transposon activity has been steadily declining in Spermophilus tridecemlineatus. More specifically, the typically ubiquitous L1 activity of mammals has decreased drastically within the last 26. MY. Indeed, only three L1 insertions with intact ORF1 sequences were readily identifiable and no intact ORF2 sequences were identified. The last L1 and SINE insertions date to ~. 5.3. MYA and 4. MYA, respectively. Based on our inability to computationally identify recently inserted L1 elements we suggest that S. tridecemlineatus is experiencing a quiescence or extinction of non-LTR retrotransposon activity. Such a finding represents only the fourth instance of a loss of non-LTR retrotransposon activity identified in mammals and, as such, represents an important additional data point to guide our understanding of LINE dynamics in eutherians.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalGene
Volume500
Issue number1
DOIs
StatePublished - May 25 2012

Keywords

  • Ground squirrel
  • LINE
  • Retrotransposon
  • Transposable element

Fingerprint Dive into the research topics of 'A non-LTR retroelement extinction in Spermophilus tridecemlineatus'. Together they form a unique fingerprint.

  • Cite this