A new highly effective anticysticercosis vaccine expressed in transgenic papaya

Marisela Hernández; José Luis Cabrera-Ponce; Gladis Fragoso; Fernando López-Casillas; Arturo Guevara-García; Gabriela Rosas; Claudia León-Ramírez; Patricia Juárez; Guadalupe Sánchez-García; Jaquelynne Cervantes; Gonzalo Acero; Andrea Toledo; Carmen Cruz; Rafael Bojalil; Luis Herrera-Estrella; Edda Sciutto

doi:10.1016/j.vaccine.2007.02.080

A new highly effective anticysticercosis vaccine expressed in transgenic papaya

Marisela Hernández, José Luis Cabrera-Ponce, Gladis Fragoso, Fernando López-Casillas, Arturo Guevara-García, Gabriela Rosas, Claudia León-Ramírez, Patricia Juárez, Guadalupe Sánchez-García, Jaquelynne Cervantes, Gonzalo Acero, Andrea Toledo, Carmen Cruz, Rafael Bojalil, Luis Herrera-Estrella, Edda Sciutto

Plant & Soil Science

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.

Original language	English
Pages (from-to)	4252-4260
Number of pages	9
Journal	Vaccine
Volume	25
Issue number	21
DOIs	https://doi.org/10.1016/j.vaccine.2007.02.080
State	Published - May 22 2007

Keywords

Anti-cysticercosis vaccine
Cysticercosis control
Transgenic papaya

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Hernández, M., Cabrera-Ponce, J. L., Fragoso, G., López-Casillas, F., Guevara-García, A., Rosas, G., León-Ramírez, C., Juárez, P., Sánchez-García, G., Cervantes, J., Acero, G., Toledo, A., Cruz, C., Bojalil, R., Herrera-Estrella, L., & Sciutto, E. (2007). A new highly effective anticysticercosis vaccine expressed in transgenic papaya. Vaccine, 25(21), 4252-4260. https://doi.org/10.1016/j.vaccine.2007.02.080

Hernández, Marisela ; Cabrera-Ponce, José Luis ; Fragoso, Gladis ; López-Casillas, Fernando ; Guevara-García, Arturo ; Rosas, Gabriela ; León-Ramírez, Claudia ; Juárez, Patricia ; Sánchez-García, Guadalupe ; Cervantes, Jaquelynne ; Acero, Gonzalo ; Toledo, Andrea ; Cruz, Carmen ; Bojalil, Rafael ; Herrera-Estrella, Luis ; Sciutto, Edda. / A new highly effective anticysticercosis vaccine expressed in transgenic papaya. In: Vaccine. 2007 ; Vol. 25, No. 21. pp. 4252-4260.

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title = "A new highly effective anticysticercosis vaccine expressed in transgenic papaya",

abstract = "The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.",

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Hernández, M, Cabrera-Ponce, JL, Fragoso, G, López-Casillas, F, Guevara-García, A, Rosas, G, León-Ramírez, C, Juárez, P, Sánchez-García, G, Cervantes, J, Acero, G, Toledo, A, Cruz, C, Bojalil, R, Herrera-Estrella, L & Sciutto, E 2007, 'A new highly effective anticysticercosis vaccine expressed in transgenic papaya', Vaccine, vol. 25, no. 21, pp. 4252-4260. https://doi.org/10.1016/j.vaccine.2007.02.080

A new highly effective anticysticercosis vaccine expressed in transgenic papaya. / Hernández, Marisela; Cabrera-Ponce, José Luis; Fragoso, Gladis; López-Casillas, Fernando; Guevara-García, Arturo; Rosas, Gabriela; León-Ramírez, Claudia; Juárez, Patricia; Sánchez-García, Guadalupe; Cervantes, Jaquelynne; Acero, Gonzalo; Toledo, Andrea; Cruz, Carmen; Bojalil, Rafael; Herrera-Estrella, Luis; Sciutto, Edda.

In: Vaccine, Vol. 25, No. 21, 22.05.2007, p. 4252-4260.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A new highly effective anticysticercosis vaccine expressed in transgenic papaya

AU - Hernández, Marisela

AU - Cabrera-Ponce, José Luis

AU - Fragoso, Gladis

AU - López-Casillas, Fernando

AU - Guevara-García, Arturo

AU - Rosas, Gabriela

AU - León-Ramírez, Claudia

AU - Juárez, Patricia

AU - Sánchez-García, Guadalupe

AU - Cervantes, Jaquelynne

AU - Acero, Gonzalo

AU - Toledo, Andrea

AU - Cruz, Carmen

AU - Bojalil, Rafael

AU - Herrera-Estrella, Luis

AU - Sciutto, Edda

PY - 2007/5/22

Y1 - 2007/5/22

N2 - The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.

AB - The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.

KW - Anti-cysticercosis vaccine

KW - Cysticercosis control

KW - Transgenic papaya

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M3 - Article

C2 - 17399859

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JO - Vaccine

JF - Vaccine

SN - 0264-410X

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