A new highly effective anticysticercosis vaccine expressed in transgenic papaya

Marisela Hernández, José Luis Cabrera-Ponce, Gladis Fragoso, Fernando López-Casillas, Arturo Guevara-García, Gabriela Rosas, Claudia León-Ramírez, Patricia Juárez, Guadalupe Sánchez-García, Jaquelynne Cervantes, Gonzalo Acero, Andrea Toledo, Carmen Cruz, Rafael Bojalil, Luis Herrera-Estrella, Edda Sciutto

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.

Original languageEnglish
Pages (from-to)4252-4260
Number of pages9
JournalVaccine
Volume25
Issue number21
DOIs
StatePublished - May 22 2007

Keywords

  • Anti-cysticercosis vaccine
  • Cysticercosis control
  • Transgenic papaya

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