A new halo aldol reaction: Three-component reaction via 1,4-robust activation of ethynyl alkyl ketones for stereoselective formations of versatile aldol adducts

Han Xun Wei, Sun Hee Kim, Guigen Li

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

(graph presented) A new three-component halo aldol reaction has been discovered for the tandem formations of I-C/C-C bonds by activating the α′,β-positions of α,β-acetylenic ketones. The key intermediates, 1-iodo-3-siloxy-1,3-butadienes, were generated from allenolates and directly monitored by 1H NMR spectroscopic analysis. Excellent geometric selectivity (>95%) and good yields (65-82%) have been achieved for 10 examples.

Original languageEnglish
Pages (from-to)3691-3693
Number of pages3
JournalOrganic Letters
Volume4
Issue number21
DOIs
StatePublished - Oct 17 2002

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