A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation

Bo Jiang, Mian Shuai Yi, Feng Shi, Shu Jiang Tu, Suresh Pindi, Patrick Mc Dowell, Guigen Li

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

Original languageEnglish
Pages (from-to)808-810
Number of pages3
JournalChemical Communications
Volume48
Issue number6
DOIs
StatePublished - Dec 14 2012

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