A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation

Bo Jiang; Mian Shuai Yi; Feng Shi; Shu Jiang Tu; Suresh Pindi; Patrick Mc Dowell; Guigen Li

doi:10.1039/c1cc15913e

A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation

Bo Jiang, Mian Shuai Yi, Feng Shi, Shu Jiang Tu, Suresh Pindi, Patrick Mc Dowell, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

Original language	English
Pages (from-to)	808-810
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	6
DOIs	https://doi.org/10.1039/c1cc15913e
State	Published - Dec 14 2012

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abstract = "A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.",

author = "Bo Jiang and Yi, {Mian Shuai} and Feng Shi and Tu, {Shu Jiang} and Suresh Pindi and {Mc Dowell}, Patrick and Guigen Li",

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AU - Jiang, Bo

AU - Yi, Mian Shuai

AU - Shi, Feng

AU - Tu, Shu Jiang

AU - Pindi, Suresh

AU - Mc Dowell, Patrick

AU - Li, Guigen

PY - 2012/12/14

Y1 - 2012/12/14

N2 - A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

AB - A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

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M3 - Article

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AN - SCOPUS:84055182866

SN - 1359-7345

VL - 48

SP - 808

EP - 810

JO - Chemical Communications

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ER -

A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation

Abstract

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