A model selection approach for expression quantitative trait loci (eQTL) mapping

Ping Wang, John A. Dawson, Mark P. Keller, Brian S. Yandell, Nancy A. Thornberry, Bei B. Zhang, I. Ming Wang, Eric E. Schadt, Alan D. Attie, C. Kendziorski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Identifying the genetic basis of complex traits remains an important and challenging problem with the potential to affect a broad range of biological endeavors. A number of statistical methods are available for mapping quantitative trait loci (QTL), but their application to high-throughput phenotypes has been limited as most require user input and interaction. Recently, methods have been developed specifically for expression QTL (eQTL) mapping, but they too are limited in that they do not allow for interactions and QTL of moderate effect. We here propose an automated model-selection-based approach that identifies multiple eQTL in experimental populations, allowing for eQTL of moderate effect and interactions. Output can be used to identify groups of transcripts that are likely coregulated, as demonstrated in a study of diabetes in mouse.

Original languageEnglish
Pages (from-to)611-621
Number of pages11
JournalGenetics
Volume187
Issue number2
DOIs
StatePublished - Feb 2011

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