TY - GEN
T1 - A model of Alzheimer's disease and mild cognitive impairment based on EEG coherence
AU - Akrofi, Kwaku
AU - Baker, Mary C.
AU - O'Boyle, Michael W.
AU - Schiffer, Randolph B.
PY - 2009
Y1 - 2009
N2 - EEG coherence was used to model the integrity of neural connectivity in patients with Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and age-matched controls. Our model was derived from the EEG data of 16 AD patients, 24 MCI patients and 16 age-matched controls. We computed the coherence of the relevant channel pairs believed to represent fiber pathways. Coherence values were compared across groups of AD patients, MCI patients, and controls, and the Kruskal-Wallis test was used to determine those channel pairs that exhibited significant differences between MCI or AD patients and controls. Because increased and decreased EEG coherence (relative to controls) has been found to be associated with fiber damage, channel pairs showing significant differences in EEG coherence were rated as damaged. The data show that while AD patients have more damaged pathways than MCI patients, the areas of damage are similar for both groups. The significance of this model is its future application (perhaps in conjunction with white matter imaging techniques) to the development of connectivity models of cognitive decline in AD and MCI patients.
AB - EEG coherence was used to model the integrity of neural connectivity in patients with Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and age-matched controls. Our model was derived from the EEG data of 16 AD patients, 24 MCI patients and 16 age-matched controls. We computed the coherence of the relevant channel pairs believed to represent fiber pathways. Coherence values were compared across groups of AD patients, MCI patients, and controls, and the Kruskal-Wallis test was used to determine those channel pairs that exhibited significant differences between MCI or AD patients and controls. Because increased and decreased EEG coherence (relative to controls) has been found to be associated with fiber damage, channel pairs showing significant differences in EEG coherence were rated as damaged. The data show that while AD patients have more damaged pathways than MCI patients, the areas of damage are similar for both groups. The significance of this model is its future application (perhaps in conjunction with white matter imaging techniques) to the development of connectivity models of cognitive decline in AD and MCI patients.
UR - http://www.scopus.com/inward/record.url?scp=67650681126&partnerID=8YFLogxK
U2 - 10.1109/ICCME.2009.4906629
DO - 10.1109/ICCME.2009.4906629
M3 - Conference contribution
AN - SCOPUS:67650681126
SN - 9781424433162
T3 - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
BT - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
Y2 - 9 April 2009 through 11 April 2009
ER -