A mild procedure for the stereospecific transformation of trans cinnamic acid derivatives to cis β-bromostyrenes

Sun Hee Kim, Han Xun Wei, Steven Willis, Guigen Li

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A new mild procedure has been developed for the synthesis of cis β- bromostyrene analogs with complete Z/E selectivity and good to excellent yields (58.4 - 90.9 %). The process involves carboxyl-halo-elimination of cinnamic acid dibromides by using triethylamine in N,N-dimethylformamide at room temperature. A one-pot procedure has also been described for the direct transformation of cinnamic acids to β-bromostyrenes.

Original languageEnglish
Pages (from-to)4179-4185
Number of pages7
JournalSynthetic Communications
Volume29
Issue number23
DOIs
StatePublished - 1999

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