A microcantilever-based pathogen detector

B. L. Weeks; J. Camarero; A. Noy; A. E. Miller; L. Stanker; J. J. De Yoreo

A microcantilever-based pathogen detector

B. L. Weeks, J. Camarero, A. Noy, A. E. Miller, L. Stanker, J. J. De Yoreo

Chemical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micromechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

Original language	English
Title of host publication	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Editors	M. Laudon, B. Romanowicz
Pages	123-125
Number of pages	3
State	Published - 2003
Event	2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States Duration: Feb 23 2003 → Feb 27 2003

Publication series

Name	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume	1

Conference

Conference	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Country/Territory	United States
City	San Francisco, CA
Period	02/23/03 → 02/27/03

Keywords

Biosensor
Cantilever
Immunosensor
Microfabrication
Surface functionalization

Cite this

@inproceedings{35610bdbcf034375a16cd0e7f0529445,

title = "A microcantilever-based pathogen detector",

abstract = "The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micromechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.",

keywords = "Biosensor, Cantilever, Immunosensor, Microfabrication, Surface functionalization",

author = "Weeks, {B. L.} and J. Camarero and A. Noy and Miller, {A. E.} and L. Stanker and {De Yoreo}, {J. J.}",

year = "2003",

language = "English",

isbn = "0972842209",

series = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",

pages = "123--125",

editor = "M. Laudon and B. Romanowicz",

booktitle = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",

note = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003 ; Conference date: 23-02-2003 Through 27-02-2003",

}

Weeks, BL, Camarero, J, Noy, A, Miller, AE, Stanker, L & De Yoreo, JJ 2003, A microcantilever-based pathogen detector. in M Laudon & B Romanowicz (eds), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003. 2003 Nanotechnology Conference and Trade Show - Nanotech 2003, vol. 1, pp. 123-125, 2003 Nanotechnology Conference and Trade Show - Nanotech 2003, San Francisco, CA, United States, 02/23/03.

A microcantilever-based pathogen detector. / Weeks, B. L.; Camarero, J.; Noy, A. et al.
2003 Nanotechnology Conference and Trade Show - Nanotech 2003. ed. / M. Laudon; B. Romanowicz. 2003. p. 123-125 (2003 Nanotechnology Conference and Trade Show - Nanotech 2003; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A microcantilever-based pathogen detector

AU - Weeks, B. L.

AU - Camarero, J.

AU - Noy, A.

AU - Miller, A. E.

AU - Stanker, L.

AU - De Yoreo, J. J.

PY - 2003

Y1 - 2003

N2 - The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micromechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

AB - The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micromechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

KW - Biosensor

KW - Cantilever

KW - Immunosensor

KW - Microfabrication

KW - Surface functionalization

UR - http://www.scopus.com/inward/record.url?scp=6344293975&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:6344293975

SN - 0972842209

SN - 9780972842204

T3 - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

SP - 123

EP - 125

BT - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

A2 - Laudon, M.

A2 - Romanowicz, B.

T2 - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

Y2 - 23 February 2003 through 27 February 2003

ER -

A microcantilever-based pathogen detector

Abstract

Publication series

Conference

Keywords

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