A macrocycle directed total synthesis of di-O-methylendiandrin A

Timothy H. Barnes; Kara F. Johnson; John Gorden; Bradley L. Merner

doi:10.1039/d0cc03302b

A macrocycle directed total synthesis of di-O-methylendiandrin A

Timothy H. Barnes, Kara F. Johnson, John Gorden, Bradley L. Merner

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of di-<italic>O</italic>-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone, to establish stereochemistry and the strained ring of the natural product.

Original language	English
Pages (from-to)	8747-8749
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d0cc03302b
State	Published - Nov 2020

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title = "A macrocycle directed total synthesis of di-O-methylendiandrin A",

abstract = "The synthesis of di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone, to establish stereochemistry and the strained ring of the natural product.",

author = "Barnes, {Timothy H.} and Johnson, {Kara F.} and John Gorden and Merner, {Bradley L.}",

year = "2020",

month = nov,

doi = "10.1039/d0cc03302b",

language = "English",

pages = "8747--8749",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry (RSC)",

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AU - Barnes, Timothy H.

AU - Johnson, Kara F.

AU - Gorden, John

AU - Merner, Bradley L.

PY - 2020/11

Y1 - 2020/11

N2 - The synthesis of di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone, to establish stereochemistry and the strained ring of the natural product.

AB - The synthesis of di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone, to establish stereochemistry and the strained ring of the natural product.

U2 - 10.1039/d0cc03302b

DO - 10.1039/d0cc03302b

M3 - Article

SN - 1359-7345

SP - 8747

EP - 8749

JO - Chemical Communications

JF - Chemical Communications

ER -

A macrocycle directed total synthesis of di-O-methylendiandrin A

Abstract

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