A distribution of tumor size at detection and its limiting form

A. Y. Yakovlev, L. G. Hanin, S. T. Rachev, A. D. Tsodikov

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A distribution of tumor size at detection is derived within the framework of a mechanistic model of carcinogenesis with the object of estimating biologically meaningful parameters of tumor latency. Its limiting form appears to be a generalization of the distribution that arises in the length-biased sampling from stationary point processes. The model renders the associated estimation problems tractable. The usefulness of the proposed approach is illustrated with an application to clinical data on premenopausal breast cancer.

Original languageEnglish
Pages (from-to)6671-6675
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number13
DOIs
StatePublished - Jun 25 1996

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