A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.

Hemachandra Reddy; Sahil Tonk; Subodh Kumar; Murali Vijayan; Ramesh Kandimalla; Chandra Sekhar Kuruva; Arubala Reddy

A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.

Hemachandra Reddy, Sahil Tonk, Subodh Kumar, Murali Vijayan, Ramesh Kandimalla, Chandra Sekhar Kuruva, Arubala Reddy

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have drugs or agents that can delay, or prevent AD and its progression, and we still do not have early detectable biomarkers for AD. Multiple cellular changes have been implicated in AD, including synaptic damage, mitochondrial damage, production and accumulation of Aβ and phosphorylated tau, inflammatory response, deficits in neurotransmitters, deregulation of the cell cycle, and hormonal imbalance. Research into AD has revealed that miRNAs are involved in each of these cellular changes and interfere with gene regulation and translation. Recent discoveries in molecular biology have also revealed that microRNAs play a major role in post-translational regulation of gene expression. The purpose of this article is to review research that has assessed neuroprotective and neurodegenerative characteristics of microRNAs in

Original language	English
Pages (from-to)	1156-1165
Journal	Biochem. Biophys. Res. Commun.
State	Published - Feb 19 2017

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title = "A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.",

abstract = "Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have drugs or agents that can delay, or prevent AD and its progression, and we still do not have early detectable biomarkers for AD. Multiple cellular changes have been implicated in AD, including synaptic damage, mitochondrial damage, production and accumulation of Aβ and phosphorylated tau, inflammatory response, deficits in neurotransmitters, deregulation of the cell cycle, and hormonal imbalance. Research into AD has revealed that miRNAs are involved in each of these cellular changes and interfere with gene regulation and translation. Recent discoveries in molecular biology have also revealed that microRNAs play a major role in post-translational regulation of gene expression. The purpose of this article is to review research that has assessed neuroprotective and neurodegenerative characteristics of microRNAs in",

author = "Hemachandra Reddy and Sahil Tonk and Subodh Kumar and Murali Vijayan and Ramesh Kandimalla and Kuruva, {Chandra Sekhar} and Arubala Reddy",

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T1 - A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.

AU - Reddy, Hemachandra

AU - Tonk, Sahil

AU - Kumar, Subodh

AU - Vijayan, Murali

AU - Kandimalla, Ramesh

AU - Kuruva, Chandra Sekhar

AU - Reddy, Arubala

PY - 2017/2/19

Y1 - 2017/2/19

N2 - Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have drugs or agents that can delay, or prevent AD and its progression, and we still do not have early detectable biomarkers for AD. Multiple cellular changes have been implicated in AD, including synaptic damage, mitochondrial damage, production and accumulation of Aβ and phosphorylated tau, inflammatory response, deficits in neurotransmitters, deregulation of the cell cycle, and hormonal imbalance. Research into AD has revealed that miRNAs are involved in each of these cellular changes and interfere with gene regulation and translation. Recent discoveries in molecular biology have also revealed that microRNAs play a major role in post-translational regulation of gene expression. The purpose of this article is to review research that has assessed neuroprotective and neurodegenerative characteristics of microRNAs in

AB - Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have drugs or agents that can delay, or prevent AD and its progression, and we still do not have early detectable biomarkers for AD. Multiple cellular changes have been implicated in AD, including synaptic damage, mitochondrial damage, production and accumulation of Aβ and phosphorylated tau, inflammatory response, deficits in neurotransmitters, deregulation of the cell cycle, and hormonal imbalance. Research into AD has revealed that miRNAs are involved in each of these cellular changes and interfere with gene regulation and translation. Recent discoveries in molecular biology have also revealed that microRNAs play a major role in post-translational regulation of gene expression. The purpose of this article is to review research that has assessed neuroprotective and neurodegenerative characteristics of microRNAs in

M3 - Article

SP - 1156

EP - 1165

JO - Biochem. Biophys. Res. Commun.

JF - Biochem. Biophys. Res. Commun.

SN - 1090-2104

ER -