A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes

W. D. Nes, P. H. Le, L. R. Berg, G. W. Patterson, J. L. Kerwin

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Representative members in each of the four orders of Oomycetes (Phytophthora cactorum, Peronosporales;Lagenidium callinectes, L. giganteum, Lagenidiales;Saprolegnia ferax, Saprolegniales;Apodachylella completa, Leptomitales) have been examined for their ability to synthesize and polycyclize squalene-oxide (SO) to a tetracyclic product and to differentiate between cycloartenol and lanosterol metabolism to sterols. P. cactorum and L. giganteum failed to synthesize or metabolize SO, cycloartenol or lanosterol. While the other three fungi synthesized sterols via SO and lanosterol, a minor metabolism of added cycloartenol to the 4,4-desmethyl-14 α-methylcyclosteroid dehydropollinastanol was observed.

Original languageEnglish
Pages (from-to)556-558
Number of pages3
JournalExperientia
Volume42
Issue number5
DOIs
StatePublished - May 1986

Keywords

  • Oomycetes
  • cycloartenol
  • lanosterol
  • squalene-oxide
  • sterol metabolism

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