A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes

W. D. Nes; P. H. Le; L. R. Berg; G. W. Patterson; J. L. Kerwin

doi:10.1007/BF01946701

A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes

W. D. Nes, P. H. Le, L. R. Berg, G. W. Patterson, J. L. Kerwin

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Representative members in each of the four orders of Oomycetes (Phytophthora cactorum, Peronosporales;Lagenidium callinectes, L. giganteum, Lagenidiales;Saprolegnia ferax, Saprolegniales;Apodachylella completa, Leptomitales) have been examined for their ability to synthesize and polycyclize squalene-oxide (SO) to a tetracyclic product and to differentiate between cycloartenol and lanosterol metabolism to sterols. P. cactorum and L. giganteum failed to synthesize or metabolize SO, cycloartenol or lanosterol. While the other three fungi synthesized sterols via SO and lanosterol, a minor metabolism of added cycloartenol to the 4,4-desmethyl-14 α-methylcyclosteroid dehydropollinastanol was observed.

Original language	English
Pages (from-to)	556-558
Number of pages	3
Journal	Experientia
Volume	42
Issue number	5
DOIs	https://doi.org/10.1007/BF01946701
State	Published - May 1986

Keywords

Oomycetes
cycloartenol
lanosterol
squalene-oxide
sterol metabolism

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10.1007/BF01946701

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title = "A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes",

abstract = "Representative members in each of the four orders of Oomycetes (Phytophthora cactorum, Peronosporales;Lagenidium callinectes, L. giganteum, Lagenidiales;Saprolegnia ferax, Saprolegniales;Apodachylella completa, Leptomitales) have been examined for their ability to synthesize and polycyclize squalene-oxide (SO) to a tetracyclic product and to differentiate between cycloartenol and lanosterol metabolism to sterols. P. cactorum and L. giganteum failed to synthesize or metabolize SO, cycloartenol or lanosterol. While the other three fungi synthesized sterols via SO and lanosterol, a minor metabolism of added cycloartenol to the 4,4-desmethyl-14 α-methylcyclosteroid dehydropollinastanol was observed.",

keywords = "Oomycetes, cycloartenol, lanosterol, squalene-oxide, sterol metabolism",

author = "Nes, {W. D.} and Le, {P. H.} and Berg, {L. R.} and Patterson, {G. W.} and Kerwin, {J. L.}",

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T1 - A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes

AU - Nes, W. D.

AU - Le, P. H.

AU - Berg, L. R.

AU - Patterson, G. W.

AU - Kerwin, J. L.

PY - 1986/5

Y1 - 1986/5

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KW - Oomycetes

KW - cycloartenol

KW - lanosterol

KW - squalene-oxide

KW - sterol metabolism

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A comparison of cycloartenol and lanosterol biosynthesis and metabolism by the Oomycetes

Abstract

Keywords

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