TY - JOUR
T1 - A comparative genomics multitool for scientific discovery and conservation
AU - Zoonomia Consortium
AU - Genereux, Diane P.
AU - Serres, Aitor
AU - Armstrong, Joel
AU - Johnson, Jeremy
AU - Marinescu, Voichita D.
AU - Murén, Eva
AU - Juan, David
AU - Bejerano, Gill
AU - Casewell, Nicholas R.
AU - Chemnick, Leona G.
AU - Damas, Joana
AU - Di Palma, Federica
AU - Diekhans, Mark
AU - Fiddes, Ian T.
AU - Garber, Manuel
AU - Gladyshev, Vadim N.
AU - Goodman, Linda
AU - Haerty, Wilfried
AU - Houck, Marlys L.
AU - Hubley, Robert
AU - Kivioja, Teemu
AU - Koepfli, Klaus Peter
AU - Kuderna, Lukas F.K.
AU - Lander, Eric S.
AU - Meadows, Jennifer R.S.
AU - Murphy, William J.
AU - Nash, Will
AU - Noh, Hyun Ji
AU - Nweeia, Martin
AU - Pfenning, Andreas R.
AU - Pollard, Katherine S.
AU - Ray, David A.
AU - Shapiro, Beth
AU - Smit, Arian F.A.
AU - Springer, Mark S.
AU - Steiner, Cynthia C.
AU - Swofford, Ross
AU - Taipale, Jussi
AU - Teeling, Emma C.
AU - Turner-Maier, Jason
AU - Alfoldi, Jessica
AU - Birren, Bruce
AU - Ryder, Oliver A.
AU - Lewin, Harris A.
AU - Paten, Benedict
AU - Marques-Bonet, Tomas
AU - Lindblad-Toh, Kerstin
AU - Karlsson, Elinor K.
N1 - Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/12
Y1 - 2020/11/12
N2 - The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
AB - The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
UR - http://www.scopus.com/inward/record.url?scp=85079408349&partnerID=8YFLogxK
U2 - 10.1038/s41586-020-2876-6
DO - 10.1038/s41586-020-2876-6
M3 - Article
C2 - 33177664
AN - SCOPUS:85079408349
VL - 587
SP - 240
EP - 245
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7833
ER -