A benchtop capillary flow layer-by-layer (CF-LbL) platform for rapid assembly and screening of biodegradable nanolayered films

Ziye Dong, Ling Tang, Caroline C. Ahrens, Zhenya Ding, Vi Cao, Steven Castleberry, Jiangtao Yan, Wei Li

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Capillary flow layer-by-layer (CF-LbL) is a microfluidic platform for high throughput preparation and screening of nanolayered polymer films. Using a simple benchtop version of CF-LbL, we systematically studied the effects of various flow conditions and channel geometries on the thickness and surface roughness of the resulting films. We also investigated the biocompatibility and degradation behaviors of a series of enzymatically-degradable films made from naturally derived polymers, i.e. either alginate or hyaluronic acid as the anionic species and poly-l-arginine as the positive species. Furthermore, using one optimized film formulation for coating on the inside walls of a microfluidic chip, we successfully demonstrated the ability of this film to capture and rapidly release cancer cells from whole blood. This simple platform is expected to be a powerful tool to increase the accessibility of the LbL film assembly to a broader scientific community.

Original languageEnglish
Pages (from-to)4601-4611
Number of pages11
JournalLab on a Chip
Volume16
Issue number23
DOIs
StatePublished - 2016

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