TY - JOUR
T1 - 4,4,14α-Trimethyl 9β,19-cyclo-5α-26-homocholesta-24,26-dien-3β-ol
T2 - A potent mechanism-based inactivator of Δ(24(25))- to Δ(25(27))-sterol methyl transferase
AU - Nes, W. David
AU - He, Ling
AU - Mangla, Anil T.
PY - 1998/12/15
Y1 - 1998/12/15
N2 - The title compound (4A) was synthesized and tested as a mechanism-based inactivator of the sterol methyl transferase (SMT) enzyme from Prototheca wickerhamii. Using cycloartenol as substrate, 4A was found to exhibit time- dependent inactivation kinetics, generating a K(i) value of 30 μM and K(inact) value of 0.30 min-1.
AB - The title compound (4A) was synthesized and tested as a mechanism-based inactivator of the sterol methyl transferase (SMT) enzyme from Prototheca wickerhamii. Using cycloartenol as substrate, 4A was found to exhibit time- dependent inactivation kinetics, generating a K(i) value of 30 μM and K(inact) value of 0.30 min-1.
UR - http://www.scopus.com/inward/record.url?scp=0032535130&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00651-9
DO - 10.1016/S0960-894X(98)00651-9
M3 - Article
C2 - 9934450
AN - SCOPUS:0032535130
SN - 0960-894X
VL - 8
SP - 3449
EP - 3452
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -