4,4,14α-Trimethyl 9β,19-cyclo-5α-26-homocholesta-24,26-dien-3β-ol: A potent mechanism-based inactivator of Δ(24(25))- to Δ(25(27))-sterol methyl transferase

W. David Nes, Ling He, Anil T. Mangla

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The title compound (4A) was synthesized and tested as a mechanism-based inactivator of the sterol methyl transferase (SMT) enzyme from Prototheca wickerhamii. Using cycloartenol as substrate, 4A was found to exhibit time- dependent inactivation kinetics, generating a K(i) value of 30 μM and K(inact) value of 0.30 min-1.

Original languageEnglish
Pages (from-to)3449-3452
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number24
DOIs
StatePublished - Dec 15 1998

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