TY - GEN
T1 - 3D core-shell simulation of hydrogel swelling behavior for controlled drug delivery
AU - Wang, Jilong
AU - Qiu, Jenny
AU - Wang, Shiren
PY - 2013
Y1 - 2013
N2 - In this paper, a three-dimensional dynamic model describing drug delivery and swelling behavior of polyelectrolyte gels was developed based on the Maxwell-Stefan equation and Bio-heat equation. COMSOL software was employed to simulate hydrogel swelling and the transportation of created automatically by COMSOL, and it had 78035 elements, which was unconcerned with the results. The results showed that Maxwell-Stefan equation and Bio-heat equation were suitable for modeling hydrogel behavior of swelling with temperature change. In addition, when temperature increased, the hydrogel swelling increased which also intensified drug release.
AB - In this paper, a three-dimensional dynamic model describing drug delivery and swelling behavior of polyelectrolyte gels was developed based on the Maxwell-Stefan equation and Bio-heat equation. COMSOL software was employed to simulate hydrogel swelling and the transportation of created automatically by COMSOL, and it had 78035 elements, which was unconcerned with the results. The results showed that Maxwell-Stefan equation and Bio-heat equation were suitable for modeling hydrogel behavior of swelling with temperature change. In addition, when temperature increased, the hydrogel swelling increased which also intensified drug release.
UR - http://www.scopus.com/inward/record.url?scp=84903455523&partnerID=8YFLogxK
U2 - 10.1115/IMECE2013-65070
DO - 10.1115/IMECE2013-65070
M3 - Conference contribution
AN - SCOPUS:84903455523
SN - 9780791856222
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013
Y2 - 15 November 2013 through 21 November 2013
ER -