3D core-shell simulation of hydrogel swelling behavior for controlled drug delivery

Jilong Wang, Jenny Qiu, Shiren Wang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

In this paper, a three-dimensional dynamic model describing drug delivery and swelling behavior of polyelectrolyte gels was developed based on the Maxwell-Stefan equation and Bio-heat equation. COMSOL software was employed to simulate hydrogel swelling and the transportation of created automatically by COMSOL, and it had 78035 elements, which was unconcerned with the results. The results showed that Maxwell-Stefan equation and Bio-heat equation were suitable for modeling hydrogel behavior of swelling with temperature change. In addition, when temperature increased, the hydrogel swelling increased which also intensified drug release.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Print)9780791856222
DOIs
StatePublished - 2013
EventASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013 - San Diego, CA, United States
Duration: Nov 15 2013Nov 21 2013

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3 B

Conference

ConferenceASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013
CountryUnited States
CitySan Diego, CA
Period11/15/1311/21/13

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