• 5165 Citations (Scopus)
  • 41 h-Index
1977 …2020

Research output per year

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Scholarly Research

  • 5165 Citations (Scopus)
  • 41 h-Index
  • 207 Article
  • 7 Review article
  • 4 Chapter
  • 1 Editorial
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Article
2020

A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity

Zhou, W., Fisher, P. M., Vanderloop, B. H., Shen, Y., Shi, H., Maldonado, A. J., Leaver, D. J. & Nes, W. D., Feb 1 2020, In : Journal of lipid research. 61, 2, p. 192-204 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens

Warrilow, A. G. S., Parker, J. E., Price, C. L., Rolley, N. J., Nes, W. D., Kelly, D. E. & Kelly, S. L., Oct 2019, In : International Journal of Antimicrobial Agents. 54, 4, p. 449-455 7 p.

Research output: Contribution to journalArticle

Isavuconazole and voriconazole inhibtion of sterol 14alpha demethylases (CYP51) from Aspergillus fumigatus and Homo Sapiens.

Warrilow, A. A., Parker, J. E., Price, C. L., Rolley, R. J., Nes, W., Kelly, D. E. & Kelly, S. L., Jul 15 2019, In : Internation Journal of Antimcirobial Agents. p. 449-455

Research output: Contribution to journalArticle

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Nes, W., Ramos, E., Zhu, X., Fisher, P. M., Kidane, M. E., Vanderloop, B. H., Thomas, C. D., Singha, U., Chaudhuri, M., Nagel, M. T. & Nes, W. D., May 10 2019, In : Journal of Lipid Research. p. 981-994

Research output: Contribution to journalArticle

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Zhou, W., Ramos, E., Zhu, X., Fisher, P. M., Kidane, M. E., Vanderloop, B. H., Thomas, C. D., Yan, J., Singha, U., Chaudhuri, M., Nagel, M. T. & David Nes, W., 2019, In : Journal of lipid research. 60, 5, p. 981-994 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Dec 14 2018, In : Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

Zhou, W., Debnath, A., Jennings, G., Hahn, H. J., Vanderloop, B. H., Chaudhuri, M., Nes, W. D. & Podust, L. M., Sep 2018, In : PLoS Pathogens. 14, 9, e1007245.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii

Zhou, W., Warrilow, A. G. S., Thomas, C. D., Ramos, E., Parker, J. E., Price, C. L., Vanderloop, B. H., Fisher, P. M., Loftis, M. D., Kelly, D. E., Kelly, S. L. & Nes, W. D., Oct 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 10, p. 1164-1178 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sterol 14α-Demethylase Structure-Based Design of VNI ((R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Blobaum, A. L., Rachakonda, G., Lindsley, C. W., Villalta, F., Nes, W. D., Botta, M., Guengerich, F. P. & Lepesheva, G. I., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5679-5691 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

Friggeri, L., Hargrove, T. Y., Rachakonda, G., Blobaum, A. L., Fisher, P., De Oliveira, G. M., Da Silva, C. F., Soeiro, M. D. N. C., Nes, W. D., Lindsley, C. W., Villalta, F., Guengerich, F. P. & Lepesheva, G. I., Dec 13 2018, In : Journal of Medicinal Chemistry. 61, 23, p. 10910-10921 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei

Miller, M. B., Patkar, P., Singha, U. K., Chaudhuri, M. & David Nes, W., Mar 1 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

CYP51 is an essential drug target for the treatment of primary amebic meningoencephalitis (PAM)

Nes, W., Calvet, C. M., Jennings, G., Zhou, W., Aksenov, A., Luth, M. R., Abagyn, R., Nes, W. D., Mckerrow, J. H. & Podust, L. M., Dec 15 2017, In : Plos Neglected Tropical Disease. p. e0006104

Research output: Contribution to journalArticle

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

Debnath, A., Calvet, C. M., Jennings, G., Zhou, W., Aksenov, A., Luth, M. R., Abagyan, R., Nes, W. D., McKerrow, J. H. & Podust, L. M., Dec 1 2017, In : PLoS neglected tropical diseases. 11, 12, p. e0006104

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

Kidane, M. E., Vanderloop, B. H., Zhou, W., Thomas, C. D., Ramos, E., Singha, U., Chaudhuri, M. & Nes, W. D., 2017, In : Journal of lipid research. 58, 12, p. 2310-2323 14 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Sterol methyltransferase a target for anti-amoeba therapy: Towards transition state analog and suicide substrate design

Nes, W., Vanderloop, B., Chaudhuri, M., Zhou, W., Thomas, C. D., Ramos, E., Singha, U. & Nes, W. D., Dec 15 2017, In : Journal of Lipid Research. p. 2310-23-33

Research output: Contribution to journalArticle

Substrate specificity and unusual reaction mechanisms of the sterol 4-methyltransferase n Caenorhabdtis elegans

Nes, W., Zhou, W., Miller, M. B., Shi, H. & Nes, W. D., Apr 15 2017, In : FASEB J.. p. 1

Research output: Contribution to journalArticle

The tetrazole VT-1161 is a potent inhibitor of Trichophyton rubrum throigh its inhibition of T. reubrum CYP51

Nes, W., Parker, J. E., Price, C. L., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Wiederhold, N. P., Nes, W. D., Kelly, D. E. & Kelly, S. L., Apr 1 2017, In : Antiimicrobial Agents & Chemotherapy. p. e00333-17

Research output: Contribution to journalArticle

The tetrazole VT-1161 is a potent inhibitor of Trichophyton rubrum throigh its inhibition of T. reubrum CYP51

Nes, W., Parker, J. E., Price, C. L., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Wiederhold, N. P., Nes, W. D., Kelly, D. E. & Kelly, S. L., Apr 1 2017, In : Antiimicrobial Agents & Chemotherapy. p. e00333-17

Research output: Contribution to journalArticle

The tetrazole VT-1161 is a potent inhibitor of Trichophyton rubrum through its inhibition of T. rubrum CYP51

Warrilow, A. G. S., Parker, J. E., Price, C. L., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Wiederhold, N. P., Nes, W. D., Kelly, D. E. & Kelly, S. L., Jul 2017, In : Antimicrobial Agents and Chemotherapy. 61, 7, e00333-17.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Azole antifungal sensitivity of sterol 14α-demethylase (CYP51) and CYP5218 from malassezia globosa

Warrilow, A. G. S., Price, C. L., Parker, J. E., Rolley, N. J., Smyrniotis, C. J., Hughes, D. D., Thoss, V., Nes, W. D., Kelly, D. E., Holman, T. R. & Kelly, S. L., Jun 13 2016, In : Scientific reports. 6, 27690.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The investigational drug VT-1129 is a highly potent inhibitor of Cryptococcus species CYP51 but only weakly inhibits the human enzyme

Warrilow, A. G. S., Parker, J. E., Price, C. L., Nes, W. D., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Kelly, D. E. & Kelly, S. L., Aug 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4530-4538 9 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2015

2014 G.J. Schroepfer Jr. Memorial AOCS Sterol Symposium: Recent Advances in Sterol Research

Moreau, R. A., Bach, T. J., Nes, W. D., Parish, E. J., Moser, J. K. & Nyström, L., Aug 5 2015, In : Lipids. 50, 8, p. 719-720 2 p., 4051.

Research output: Contribution to journalArticle

Azole antifungal agents to treat the human pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through inhibition of sterol 14α-demethylase (CYP51)

Lamb, D. C., Warrilow, A. G. S., Rolley, N. J., Parker, J. E., Nes, W. D., Smith, S. N., Kelly, D. E. & Kelly, S. L., Aug 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 8, p. 4707-4713 7 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

Haubrich, B. A., Collins, E. K., Howard, A. L., Wang, Q., Snell, W. J., Miller, M. B., Thomas, C. D., Pleasant, S. K. & Nes, W. D., May 17 2015, In : Phytochemistry. 113, p. 64-72 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Discovery of an ergosterol-signaling factor that regulates trypanosoma brucei growth

Haubrich, B. A., Singha, U. K., Miller, M. B., Nes, C. R., Anyatonwu, H., Lecordier, L., Patkar, P., Leaver, D. J., Villalta, F., Vanhollebeke, B., Chaudhuri, M. & Nes, W. D., Feb 1 2015, In : Journal of lipid research. 56, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth

Nes, W., Feb 1 2015, In : Journal of Lipid Research. p. 331-341

Research output: Contribution to journalArticle

Fluorinated sterols are suicide inhibitors of ergosterol biosynthesis and growth in trypanosoma brucei

Leaver, D. J., Patkar, P., Singha, U. K., Miller, M. B., Haubrich, B. A., Chaudhuri, M. & Nes, W. D., Oct 22 2015, In : Chemistry and Biology. 22, 10, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Fluorinated sterols are suicide inhibitors of ergosterol biosynthesis and growth in Trypanosoma brucei

Nes, W., Aug 15 2015, In : Chem & Biol. p. 1374-1383

Research output: Contribution to journalArticle

GJ Schroepfer jr. memorial AOCS sterol symposium: Recent advances in sterol research.

Nes, W., Bach, T. J., Nes, W. D., Parish, E. J., Mosher, J. K. & Nystrom, L., Aug 1 2015, In : Lipids. p. 719-720

Research output: Contribution to journalArticle

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Santori, F. R., Huang, P., Van De Pavert, S. A., Douglass, E. F., Leaver, D. J., Haubrich, B. A., Keber, R., Lorbek, G., Konijn, T., Rosales, B. N., Rozman, D., Horvat, S., Rahier, A., Mebius, R. E., Rastinejad, F., Nes, W. D. & Littman, D. R., Feb 3 2015, In : Cell Metabolism. 21, 2, p. 286-298 13 p.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations

In Vitro biochemical study of CYP51-mediated azole resistance in Aspergillus fumigatus

Warrilow, A. G. S., Parker, J. E., Price, C. L., Nes, W. D., Kelly, S. L. & Kelly, D. E., Dec 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7771-7778 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Novel substrate specificity and temperature-sensitive activity of Mycosphaerella graminicola CYP51 supported by the native NADPH cytochrome p450 reductase

Price, C. L., Warrilow, A. G. S., Parker, J. E., Mullins, J. G. L., Nes, W. D., Kelly, D. E. & Kelly, S. L., 2015, In : Applied and environmental microbiology. 81, 10, p. 3379-3386 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., De Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., Van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., Jan 28 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis

Lepesheva, G. I., Hargrove, T. Y., Rachakonda, G., Wawrzak, Z., Pomel, S., Cojean, S., Nde, P. N., Nes, W. D., Locuson, C. W., Calcutt, M. W., Waterman, M. R., Daniels, J. S., Loiseau, P. M. & Villalta, F., Nov 1 2015, In : Journal of Infectious Diseases. 212, 9, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
2014

Both methylerythritol phosphate and mevalonate pathways contribute to biosynthesis of each of the major isoprenoid classes in young cotton seedlings

Opitz, S., Nes, W. D. & Gershenzon, J., Feb 2014, In : Phytochemistry. 98, p. 110-119 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: Evidence for channel switching and its phylogenetic implications

Patkar, P., Haubrich, B. A., Qi, M., Nguyen, T. T. M., Thomas, C. D. & Nes, W. D., Dec 1 2013, In : Biochemical Journal. 456, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

Miller, M. B., Haubrich, B. A., Wang, Q., Snell, W. J. & Nes, W. D., Aug 2012, In : Journal of lipid research. 53, 8, p. 1636-1645 10 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Evolutionaryily conserved delta25(27)-ergosterol biosynthesis pathway in the algal Chlamydomonas reinhardtii

Miller, M. B., Haubrich, B. A., Wang, Q., S\nell, W. J. & Nes, W., Aug 1 2012, In : J. Lipid Res.. p. 1636-1645

Research output: Contribution to journalArticle

Metabolic engineering of soybean affords improved phytosterol seed traits

Neelakandan, A. K., Chamala, S., Valliyodan, B., Nes, W. D. & Nguyen, H. T., Jan 2012, In : Plant Biotechnology Journal. 10, 1, p. 12-19 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Metabolic engineering of soybean affords improved phytosterol seed traits.

Nes, W., Neelakanda, A., Valliyodan, B., Chamala, S., Nes, W. & Nguyen, H., Jan 5 2012, In : Plant Biotech. J.. p. 12-19

Research output: Contribution to journalArticle

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Nes, C. R., Singha, U. K., Liu, J., Ganapathy, K., Villalta, F., Waterman, M. R., Lepesheva, G. I., Chaudhuri, M. & Nes, W. D., Apr 1 2012, In : Biochemical Journal. 443, 1, p. 267-277 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms.

Nes, C. R., Singha, U. K., Liu, J., Villalta, F., Waterman, M. R., Lepesheva, G. I., Chaudhuri, M. & Nes, W., Feb 3 2012, In : Biochemical Journal. p. 267-276

Research output: Contribution to journalArticle

Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence

Howard, A. L., Liu, J., Elmegeed, G. A., Collins, E. K., Ganatra, K. S., Nwogwugwu, C. A. & Nes, W. D., May 2012, In : Archives of Biochemistry and Biophysics. 521, 1-2, p. 43-50 8 p.

Research output: Contribution to journalArticle

6 Scopus citations